Metabolic host response and therapeutic approaches to influenza infection

Host Immune Response to Influenza A Virus Infection

Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory infection in humans and animals worldwide. Upon detection of IAV infection, host immune system aims to defend against and clear the viral infection. Innate immune system is comprised of physical barriers (mucus and collectins), various phagocytic cells, group of cytokines, interferons (IFNs), and IFN-stimulat...

Systemic Inflammatory Response Syndrome Due to Surgery and its Effective Therapeutic Approaches

Introduction: Various lesions trigger an inflammatory response in the host body. These injuries include surgical stress Surgery exerts stress on the body. Systemic inflammatory syndrome is a reflection of the degree of surgical stress and as a system of assessing the severity of postoperative stress. Regular complexes of inflammatory polypeptide molecules contribute to the development of this i...

Novel Therapeutic Approaches to Leishmania Infection

Metabolic syndrome: new therapeutic approaches

In the last three decades in the United States the prevalence of overweight/obesity in pediatric population has more than tripled, causing the onset also in pediatric age of diseases previously considered exclusively of adults, such as metabolic syndrome (MetS) [1]. MetS represents a cluster of cardiometabolic abnormalities, including visceral obesity, dyslipidemia, hypertension and diabetes me...

Host Transcriptional Response to Ebola Virus Infection

Ebola virus disease (EVD) is a serious illness that causes severe disease in humans and non-human primates (NHPs) and has mortality rates up to 90%. EVD is caused by the Ebolavirus and currently there are no licensed therapeutics or vaccines to treat EVD. Due to its high mortality rates and potential as a bioterrorist weapon, a better understanding of the disease is of high priority. Multiparam...